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Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

Abstract:

Even though hematopoietic stem cell (HSC) dysfunction is presumed in myelodysplastic syndrome (MDS), the exact nature of quantitative and qualitative alterations is unknown. We conducted a study of phenotypic and molecular alterations in highly fractionated stem and progenitor populations in a variety of MDS subtypes. We observed an expansion of the phenotypically primitive long-term HSCs (lineage(-)/CD34(+)/CD38(-)/CD90(+)) in MDS, which was most pronounced in higher-risk cases. These MDS HS...

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Publication status:
Published

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Authors


Vogler, TO More by this author
Ben-Neriah, S More by this author
Schinke, C More by this author
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Journal:
Blood
Volume:
120
Issue:
10
Pages:
2076-2086
Publication date:
2012-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b344ffcf-44c6-47c8-8561-7f4e0abf43bf
Source identifiers:
341226
Local pid:
pubs:341226

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