- Abstract:
-
Even though hematopoietic stem cell (HSC) dysfunction is presumed in myelodysplastic syndrome (MDS), the exact nature of quantitative and qualitative alterations is unknown. We conducted a study of phenotypic and molecular alterations in highly fractionated stem and progenitor populations in a variety of MDS subtypes. We observed an expansion of the phenotypically primitive long-term HSCs (lineage(-)/CD34(+)/CD38(-)/CD90(+)) in MDS, which was most pronounced in higher-risk cases. These MDS HS...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2011-12-399683
-
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- Journal:
- Blood
- Volume:
- 120
- Issue:
- 10
- Pages:
- 2076-2086
- Publication date:
- 2012-09-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
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0006-4971
- URN:
-
uuid:b344ffcf-44c6-47c8-8561-7f4e0abf43bf
- Source identifiers:
-
341226
- Local pid:
- pubs:341226
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.
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