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Antibody deficiency secondary to chronic lymphocytic leukemia: Should patients be treated with prophylactic replacement immunoglobulin?

Abstract:

Hypogammaglobulinemia is a common finding in chronic lymphocytic leukemia (CLL). Its incidence increases with disease duration and stage such that it is present in up to 85 % of patients at some point in their disease course. It is therefore important to monitor patients for the development of an antibody deficiency. However, not all patients with antibody deficiency secondary to CLL are symptomatic with bacterial infections. In addition patients are susceptible to viral, fungal and opportuni...

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Publication status:
Published

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Publisher copy:
10.1007/s10875-014-9995-5

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Journal of clinical immunology
Volume:
34
Issue:
3
Pages:
277-282
Publication date:
2014-04-05
DOI:
EISSN:
1573-2592
ISSN:
0271-9142
URN:
uuid:b324f51f-4a47-46bc-b1c3-cd42ef0f4a2b
Source identifiers:
449275
Local pid:
pubs:449275

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