Journal article icon

Journal article

Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease

Abstract:

IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thickness in a European population at high risk of coronary artery disease. We analysed SNPs within rob...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cyto.2016.01.007

Authors


Expand authors...
British Heart Foundation More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Ltd. Publisher's website
Journal:
Cytokine Journal website
Volume:
81
Pages:
1-9
Publication date:
2016-01-25
Acceptance date:
2016-01-18
DOI:
ISSN:
1043-4666 and 1096-0023
Pubs id:
pubs:601352
URN:
uri:b322e105-0c4f-4dc0-b0e9-3920031da8ec
UUID:
uuid:b322e105-0c4f-4dc0-b0e9-3920031da8ec
Local pid:
pubs:601352
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP