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Variable renewal rate and growth properties of cell populations in colon crypts

Abstract:

A nonlinear mathematical model is used to investigate the time evolution of the cell populations in colon crypts (stem, semidifferentiated and fully differentiated cells). To mimic pathological alteration of the biochemical pathways leading to abnormal proliferative activity of the population of semidifferentiated cells their renewal rate is assumed to be dependent on the population size. Then, the effects of such perturbation on the population dynamics are investigated theoretically. Using b...

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A Di Garbo More by this author
M. D. Johnston More by this author
S. J. Chapman More by this author
P. K. Maini More by this author
Publication date:
2010
URN:
uuid:b31a0396-80d7-4c09-932e-dbdbd7972554
Local pid:
oai:eprints.maths.ox.ac.uk:925

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