Effect of previous exposure to malaria on blood pressure in Kilifi, Kenya: a Mendelian randomization study
Background–Malaria exposure in childhood may contribute to high blood pressure (BP) in adults. We used sickle cell trait (SCT) and a+ thalassemia, genetic variants conferring partial protection against malaria, as tools to test this hypothesis.
Methods and Results –Study sites were Kilifi, Kenya, which has malaria transmission, and Nairobi, Kenya and Jackson, Mississippi, where there is no malaria transmission. The primary outcome was 24-hou... Expand abstract
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- © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.