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Effect of previous exposure to malaria on blood pressure in Kilifi, Kenya: a Mendelian randomization study

Abstract:
Background–Malaria exposure in childhood may contribute to high blood pressure (BP) in adults. We used sickle cell trait (SCT) and a+ thalassemia, genetic variants conferring partial protection against malaria, as tools to test this hypothesis.

Methods and Results –Study sites were Kilifi, Kenya, which has malaria transmission, and Nairobi, Kenya and Jackson, Mississippi, where there is no malaria transmission. The primary outcome was 24-hou... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1161/JAHA.118.011771

Authors


Kyobutungi, C More by this author
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Publisher:
American Heart Association Publisher's website
Journal:
Journal of the American Heart Association Journal website
Volume:
8
Issue:
6
Publication date:
2019-03-16
Acceptance date:
2019-02-05
DOI:
EISSN:
2047-9980
Pubs id:
pubs:969190
URN:
uri:b3197b96-3444-4f52-8425-1f64e9e055c6
UUID:
uuid:b3197b96-3444-4f52-8425-1f64e9e055c6
Local pid:
pubs:969190

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