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The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation.

Abstract:

The structure of gelsolin has been determined by crystallography and comprises six structurally related domains that, in a Ca2+-free environment, pack together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur. We propose that binding Ca2+ can release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently. Domain shifts are proposed in...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Journal:
Cell
Volume:
90
Issue:
4
Pages:
661-670
Publication date:
1997-08-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:b317700d-0781-4a6a-a45c-07fda81c67c7
Source identifiers:
18625
Local pid:
pubs:18625

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