Novel genes mapping to the critical region of the 5q- syndrome.

Journal article

The 5q- syndrome is a myelodysplastic syndrome with specific hematological features and a good prognosis. Using molecular mapping techniques, we have previously defined the critical region of gene loss of the 5q- chromosome in the 5q- syndrome as the approximately 5-Mb region at 5q31-q33 flanked by the genes for FGF1 and IL12B. This region is completely represented by a series of overlapping YACs, and we are currently generating a transcription map with the aim of identifying the tumor-suppre...

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Authors: Boultwood, J; Fidler, C; Soularue, P; Strickson, A; Kostrzewa, M

• Publication status: Published
• Journal: Genomics
• Volume: 45
• Issue: 1
• Pages: 88-96
• Publication date: 1997-10-01
• DOI: 10.1006/geno.1997.4899
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: Humans; Chromosomes, Human, Pair 5; DNA, Complementary; Gene Dosage; Chromosome Deletion; Chromosomes, Artificial, Yeast; Myelodysplastic Syndromes; Chromosome Mapping; Sequence Tagged Sites