Journal article
Expert review of global real-world data on COVID-19 vaccine booster effectiveness and safety during the omicron-dominant phase of the pandemic
- Abstract:
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Introduction
COVID-19 vaccines have been highly effective in reducing morbidity and mortality during the pandemic. However, the emergence of the Omicron variant and subvariants as the globally dominant strains have raised doubts about the effectiveness of currently available vaccines and prompted debate about potential future vaccination strategies.
Areas covered
Using the publicly available IVAC VIEW-hub platform, we reviewed 52 studies on vaccine effectiveness (VE) after booster vaccinations. VE were reported for SARS-CoV-2 symptomatic infection, severe disease and death and stratified by vaccine schedule and age. In addition, a non-systematic literature review of safety was performed to identify single or multi-country studies investigating adverse event rates for at least two of the currently available COVID-19 vaccines.
Expert opinion
Booster shots of the current COVID-19 vaccines provide consistently high protection against Omicron-related severe disease and death. Additionally, this protection appears to be conserved for at least 3 months, with a small but significant waning after that. The positive risk-benefit ratio of these vaccines is well established, giving us confidence to administer additional doses as required. Future vaccination strategies will likely include a combination of schedules based on risk profile, as overly frequent boosting may be neither beneficial nor sustainable for the general population.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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- Files:
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(Preview, Version of record, pdf, 5.5MB, Terms of use)
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- Publisher copy:
- 10.1080/14760584.2023.2143347
Authors
- Publisher:
- Taylor and Francis
- Journal:
- Expert Review of Vaccines More from this journal
- Volume:
- 22
- Issue:
- 1
- Pages:
- 1-16
- Place of publication:
- England
- Publication date:
- 2022-11-04
- Acceptance date:
- 2022-10-27
- DOI:
- EISSN:
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1744-8395
- ISSN:
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1476-0584
- Pmid:
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36330971
- Language:
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English
- Keywords:
- Pubs id:
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1300052
- Local pid:
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pubs:1300052
- Deposit date:
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2023-02-24
Terms of use
- Copyright holder:
- Solante et al
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
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