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Control of the mitotic spindle by dynein light chain 1 complexes

Abstract:

Robust control mechanisms ensure faithful inheritance of an intact genome through the processes of mitosis and cytokinesis. Different populations of the cytoplasmic dynein motor defined by specific dynein adaptor complexes are required for the formation of a stable bipolar mitotic spindle. This study analysed how different dynein subcomplexes contribute to spindle formation and orientation. Various dynein subpopulations were identified by mass spectrometry. I have shown that the dynein light ...

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Institution:
University of Oxford
Research group:
Prof. Francis Barr
Oxford college:
Somerville College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:b2fd5670-a035-42ca-aaef-78a30aeaa084
Local pid:
ora:8077
Language:
English
Keywords:
Subjects:

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