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A stochastic model for tumor control probability that accounts for repair from sublethal damage

Abstract:

The tumor control probability (TCP) is the probability that a treatment regimen of radiation therapy (RT) eradicates all tumor cells in a given tissue. To decrease the toxic effects on healthy cells, RT is usually delivered over a period of weeks in a series of fractions. This allows tumor cells to repair from sublethal damage (RSD) caused by radiation. In this paper, we introduce a stochastic model for tumor response to radiotherapy which accounts for the effects of repair from sublethal dam...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1093/imammb/dqw024

Authors


Ponce Bobadilla, AV More by this author
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Department:
St Johns College
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Department:
Oxford, MPLS, Mathematical Institute
Publisher:
Oxford University Press Publisher's website
Journal:
Mathematical Medicine and Biology Journal website
Volume:
35
Issue:
2
Pages:
181–202
Publication date:
2017-02-26
Acceptance date:
2016-12-22
DOI:
EISSN:
1477-8602
ISSN:
1477-8599
Pubs id:
pubs:667007
URN:
uri:b2f49f68-7582-47e4-86c2-78fcc3f7e9b3
UUID:
uuid:b2f49f68-7582-47e4-86c2-78fcc3f7e9b3
Local pid:
pubs:667007

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