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Journal article

The alarmin IL-33 promotes regulatory T-cell function in the intestine.

Abstract:

FOXP3(+) regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to self and environmental stimuli. It is now appreciated that Treg cells acquire tissue-specific adaptations that facilitate their survival and function; however, key host factors controlling the Treg response in the intestine are poorly understood. The interleukin (IL)-1 family member IL-33 is constitutively expressed in epithelial cells at barrier sites, where it fu...

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Publication status:
Published

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Publisher copy:
10.1038/nature13577

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Journal:
Nature
Volume:
513
Issue:
7519
Pages:
564-568
Publication date:
2014-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:b2f1c620-0446-44cd-ae2a-b7930edce7aa
Source identifiers:
477457
Local pid:
pubs:477457

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