- Abstract:
-
FOXP3(+) regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to self and environmental stimuli. It is now appreciated that Treg cells acquire tissue-specific adaptations that facilitate their survival and function; however, key host factors controlling the Treg response in the intestine are poorly understood. The interleukin (IL)-1 family member IL-33 is constitutively expressed in epithelial cells at barrier sites, where it fu...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nature13577
-
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- Journal:
- Nature
- Volume:
- 513
- Issue:
- 7519
- Pages:
- 564-568
- Publication date:
- 2014-09-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:b2f1c620-0446-44cd-ae2a-b7930edce7aa
- Source identifiers:
-
477457
- Local pid:
- pubs:477457
- Copyright date:
- 2014
Journal article
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
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