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Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition

Abstract:

Group II metabotropic glutamate receptors (mGluR2 and mGluR3, encoded by GRM2 and GRM3) are implicated in hippocampal function and cognition, and in the pathophysiology and treatment of schizophrenia and other psychiatric disorders. However, pharmacological and behavioral studies with group II mGluR agonists and antagonists have produced complex results. Here, we studied hippocampus-dependent memory in GRM2/3 double knockout (GRM2/3 -/-) mice in an iterative sequence of experiments. We found ...

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Publisher copy:
10.1038/npp.2011.145

Authors


Burnet, PWJ More by this author
Rawlins, JNP More by this author
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Journal:
Neuropsychopharmacology
Volume:
36
Issue:
13
Pages:
2616-2628
Publication date:
2011-12-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:b2edcc1b-3d92-4919-88a7-1770588be312
Source identifiers:
206392
Local pid:
pubs:206392

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