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Declining efficacy of artemisinin combination therapy against P. falciparum malaria on the Thai-Myanmar border (2003-2013): The role of parasite genetic factors.

Abstract:

Background

Deployment of mefloquine–artesunate (MAS3) on the Thailand–Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years. The role of Plasmodium falciparum K13 mutations (a marker of artemisinin resistance) in reducing treatment efficacy remains controversial.

Methods

Between 2003 and 2013, we studied the efficacy of MAS3 in 1005 patients with uncomplicated P. falciparum ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/ciw388

Authors


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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
63
Issue:
6
Pages:
784-791
Publication date:
2016-06-05
Acceptance date:
2016-06-05
DOI:
ISSN:
1537-6591 and 1058-4838
Pubs id:
pubs:628794
URN:
uri:b2cabe99-d401-4aa3-935f-05f3fcf7d90b
UUID:
uuid:b2cabe99-d401-4aa3-935f-05f3fcf7d90b
Local pid:
pubs:628794

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