Journal article icon

Journal article

2010 Young Investigator Award winner: Therapeutic aprotinin stimulates osteoblast proliferation but inhibits differentiation and bone matrix mineralization.

Abstract:

STUDY DESIGN: Analysis of the effect of antifibrinolytics on in vitro bone formation. OBJECTIVE: As the direct effect of antifibrinolytics on bone formation is unknown, we examined whether antifibrinolytics routinely used in spine surgery, namely, aprotinin and aminocaproic acid, affect osteoblast function in vitro. SUMMARY OF BACKGROUND DATA: Antifibrinolytics are used in spine surgery to prevent intraoperative blood loss and decrease the need for transfusion. They are either delivered syst...

Expand abstract

Actions


Access Document


Authors


Expand authors...
Journal:
Spine
Volume:
35
Issue:
9
Pages:
1008-1016
Publication date:
2010-04-05
DOI:
EISSN:
1528-1159
ISSN:
0362-2436
URN:
uuid:b2bccffd-58e7-4cd9-be4f-e76c54f5998e
Source identifiers:
245324
Local pid:
pubs:245324

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP