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Hippocampal 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression has a diurnal variability that is lost in the obese Zucker rat.

Abstract:

Circulating levels of glucocorticoids show a circadian rhythm. Obesity is associated with a flattening of the diurnal rhythm; plasma cortisol levels are slightly increased during the trough, although they are normal or low in the morning. Studies in humans and in leptin-resistant Zucker rats suggest that tissue-specific alterations in glucocorticoid exposure might play a key role for development of obesity and obesity-associated dysregulation of the hypothalamic-pituitary-adrenal axis. We hyp...

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Publisher copy:
10.1210/en.2006-0897

Authors


Bergström, SA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Söderström, I More by this author
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Journal:
Endocrinology
Volume:
148
Issue:
6
Pages:
2716-2722
Publication date:
2007-06-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:b2bc9e04-2783-4b2b-9155-febb458fbf89
Source identifiers:
252402
Local pid:
pubs:252402

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