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Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.

Abstract:

The stem and progenitor cell compartments in low and intermediate-risk myelodysplastic syndromes (MDS) have recently been described, and shown to be highly conserved when compared to those in acute myeloid leukemia (AML). Much less is known about the characteristics of the hematopoietic hierarchy of subgroups of MDS with a high risk of transforming to AML. Immunophenotypic analysis of immature stem and progenitor cell compartments from patients with an isolated loss of the entire chromosome 7...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.18632/oncotarget.12234

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Swedish Medical Research Council More from this funder
Tobias Foundation More from this funder
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Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Publication date:
2016-09-14
Acceptance date:
2016-09-16
DOI:
ISSN:
1949-2553
Pubs id:
pubs:648231
URN:
uri:b2a842c4-caba-4813-910f-dbde2a2cfa09
UUID:
uuid:b2a842c4-caba-4813-910f-dbde2a2cfa09
Local pid:
pubs:648231

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