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Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells.

Abstract:

Plasmodium falciparum, the protozoan parasite responsible for severe malaria infection, undergoes a complex life cycle. Infected red blood cells (iRBC) sequester in host cerebral microvessels, which underlies the pathology of cerebral malaria. Using immunohistochemistry on post mortem brain samples, we demonstrated positive staining for vascular endothelial growth factor (VEGF) on iRBC. Confocal microscopy of cultured iRBC revealed accumulation of VEGF within the parasitophorous vacuole, expr...

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Publication status:
Published

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Authors


Sachanonta, N More by this author
Medana, IM More by this author
Roberts, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand
Volume:
26
Issue:
1
Pages:
37-45
Publication date:
2008-03-05
ISSN:
0125-877X
URN:
uuid:b298dabf-1510-4fa5-9be3-7be034308947
Source identifiers:
40769
Local pid:
pubs:40769

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