Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells.
Plasmodium falciparum, the protozoan parasite responsible for severe malaria infection, undergoes a complex life cycle. Infected red blood cells (iRBC) sequester in host cerebral microvessels, which underlies the pathology of cerebral malaria. Using immunohistochemistry on post mortem brain samples, we demonstrated positive staining for vascular endothelial growth factor (VEGF) on iRBC. Confocal microscopy of cultured iRBC revealed accumulation of VEGF within the parasitophorous vacuole, expr...Expand abstract
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- Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand
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