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TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.

Abstract:

A subset of the tumour necrosis factor (TNF) receptor family contain a conserved intracellular motif, the death domain. Engagement of these receptors by their respective ligands initiates a signalling cascade that rapidly leads to cell death by apoptosis. We have cloned a new member of this family, TRICK2, the TRAIL (TNF-related apoptosis-inducing ligand) receptor inducer of cell killing 2. TRICK2 is expressed in a number of cell types, and to particularly high levels in lymphocytes and splee...

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Publication status:
Published

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Authors


Screaton, GR More by this author
Mongkolsapaya, J More by this author
Cowper, AE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
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Journal:
Current biology : CB
Volume:
7
Issue:
9
Pages:
693-696
Publication date:
1997-09-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:b297c175-e2fc-43fa-836a-9b9ff6964659
Source identifiers:
36087
Local pid:
pubs:36087

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