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Asymmetric and enantiospecific syntheses of 1-hydroxymethyl pyrrolizidine alkaloids

Abstract:
Isoretronecanol and trachelantamidine (laburnine) are naturally occurring pyrrolizidine alkaloids which display potent biological activity, and as such these compounds have, in recent years, attracted significant interest from the bioorganic and synthetic communities. This review delineates both the asymmetric and enantiospecific syntheses of 1-hydroxymethyl pyrrolizidine alkaloids including isoretronecanol, trachelantamidine (laburnine) and related hydroxylated compounds. © 2014 Elsevier Ltd. All rights reserved.
Publication status:
Published

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Authors


Brambilla, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Fletcher, AM More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Publisher:
Elsevier Ltd
Journal:
TETRAHEDRON-ASYMMETRY
Volume:
25
Issue:
5
Pages:
387-403
Publication date:
2014-03-15
DOI:
EISSN:
1362-511X
ISSN:
0957-4166
URN:
uuid:b293f37c-902f-425b-858e-4e4a2cca8a9e
Source identifiers:
459749
Local pid:
pubs:459749
Language:
English

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