- Abstract:
-
Many mechanisms have been proposed to explain why immune responses against human tumor antigens are generally ineffective. For example, tumor cells have been shown to develop active immune evasion mechanisms. Another possibility is that tumor antigens are unable to optimally stimulate tumor-specific T cells. In this study we have used HLA-A2/Melan-A peptide tetramers to directly isolate antigen-specific CD8(+) T cells from tumor-infiltrated lymph nodes. This allowed us to quantify the activat...
Expand abstract - Publisher copy:
- 10.1093/intimm/11.12.1971
-
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- Journal:
- International immunology
- Volume:
- 11
- Issue:
- 12
- Pages:
- 1971-1980
- Publication date:
- 1999-12-05
- DOI:
- EISSN:
-
1460-2377
- ISSN:
-
0953-8178
- URN:
-
uuid:b2923fdc-1cdc-42ef-851d-1e0a007a81f5
- Source identifiers:
-
31585
- Local pid:
- pubs:31585
- Copyright date:
- 1999
Journal article
Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.
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