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Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.

Abstract:

Many mechanisms have been proposed to explain why immune responses against human tumor antigens are generally ineffective. For example, tumor cells have been shown to develop active immune evasion mechanisms. Another possibility is that tumor antigens are unable to optimally stimulate tumor-specific T cells. In this study we have used HLA-A2/Melan-A peptide tetramers to directly isolate antigen-specific CD8(+) T cells from tumor-infiltrated lymph nodes. This allowed us to quantify the activat...

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Publisher copy:
10.1093/intimm/11.12.1971

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Journal:
International immunology
Volume:
11
Issue:
12
Pages:
1971-1980
Publication date:
1999-12-05
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:b2923fdc-1cdc-42ef-851d-1e0a007a81f5
Source identifiers:
31585
Local pid:
pubs:31585

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