- Abstract:
-
Precise positioning of the mitotic spindle determines the correct cell division axis and is crucial for organism development. Spindle positioning is mediated through a cortical machinery by capturing astral microtubules, thereby generating pushing/pulling forces at the cell cortex. However, the molecular link between these two structures remains elusive. Here we describe a previously uncharacterized protein, MISP (C19orf21), as a substrate of Plk1 that is required for correct mitotic spindle ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1083/jcb.201207050
-
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- Journal:
- The Journal of cell biology
- Volume:
- 200
- Issue:
- 6
- Pages:
- 773-787
- Publication date:
- 2013-03-05
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- URN:
-
uuid:b28026ad-80b0-4aed-bb5c-0c99835053ae
- Source identifiers:
-
390931
- Local pid:
- pubs:390931
- Copyright date:
- 2013
Journal article
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
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