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Journal article

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.

Abstract:

Precise positioning of the mitotic spindle determines the correct cell division axis and is crucial for organism development. Spindle positioning is mediated through a cortical machinery by capturing astral microtubules, thereby generating pushing/pulling forces at the cell cortex. However, the molecular link between these two structures remains elusive. Here we describe a previously uncharacterized protein, MISP (C19orf21), as a substrate of Plk1 that is required for correct mitotic spindle ...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.201207050

Authors


Settele, F More by this author
Sanchez-Pulido, L More by this author
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Journal:
The Journal of cell biology
Volume:
200
Issue:
6
Pages:
773-787
Publication date:
2013-03-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:b28026ad-80b0-4aed-bb5c-0c99835053ae
Source identifiers:
390931
Local pid:
pubs:390931

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