Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets.

Journal article

The nucleus basalis (NB) in the basal forebrain provides most of the cholinergic input to the neocortex and has been implicated in a variety of cognitive functions related to the processing of sensory stimuli. However, the role that cortical acetylcholine release plays in perception remains unclear. Here we show that selective loss of cholinergic NB neurons that project to the cortex reduces the accuracy with which ferrets localize brief sounds and prevents them from adaptively reweighting au...

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Authors: Leach, N; Nodal, F; Cordery, P; King, A; Bajo, V

• Publication status: Published
• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 33
• Issue: 15
• Pages: 6659-6671
• Publication date: 2013-04-01
• DOI: 10.1523/jneurosci.5039-12.2013
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Cell Death; Animals; Neuronal Plasticity; Immunotoxins; Antibodies, Monoclonal; Sound Localization; Recovery of Function; Ferrets; Ribosome Inactivating Proteins, Type 1; Cerebral Cortex; Cholinergic Neurons; Nerve Degeneration; Neural Pathways; Auditory Perception; Basal Nucleus of Meynert; Auditory Cortex; Microinjections