Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene.

Journal article

Gene expression analysis was performed on a human renal cancer cell line (786-0) with mutated VHL gene and a transfectant with wild-type VHL to analyse genes regulated by VHL and to compare with the gene programme regulated by hypoxia. There was a highly significant concordance of the global gene response to hypoxia and genes suppressed by VHL. Cyclin D1 was the most highly inducible transcript and 14-3-3 epsilon was downregulated. There were some genes regulated by VHL but not hypoxia in the...

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Authors: Wykoff, C; Sotiriou, C; Cockman, M; Ratcliffe, P; Maxwell, P

• Publication status: Published
• Journal: British journal of cancer
• Volume: 90
• Issue: 6
• Pages: 1235-1243
• Publication date: 2004-03-01
• DOI: 10.1038/sj.bjc.6601657
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Ubiquitin-Protein Ligases; Cell Hypoxia; Kidney Neoplasms; Tumor Cells, Cultured; Humans; Von Hippel-Lindau Tumor Suppressor Protein; Cyclin D1; Gene Expression Profiling; Tumor Suppressor Proteins; Carcinoma, Renal Cell