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Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure

Abstract:

The development of protective vaccines against many difficult infectious pathogens will necessitate the induction of effective antibody responses. Here we assess humoral immune responses against two antigens from the blood-stage merozoite of the Plasmodium falciparum human malaria parasite--MSP1 and AMA1. These antigens were delivered to healthy malaria-naïve adult volunteers in Phase Ia clinical trials using recombinant replication-deficient viral vectors--ChAd63 to prime the immune response...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0107903

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
9
Issue:
9
Pages:
e107903
Publication date:
2014-09-25
Acceptance date:
2014-08-17
DOI:
EISSN:
1932-6203
URN:
uuid:b2676859-c06d-43d2-84b6-8cadbc02375c
Source identifiers:
485296
Local pid:
pubs:485296
Language:
English
Keywords:

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