Journal article
Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure
- Abstract:
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The development of protective vaccines against many difficult infectious pathogens will necessitate the induction of effective antibody responses. Here we assess humoral immune responses against two antigens from the blood-stage merozoite of the Plasmodium falciparum human malaria parasite--MSP1 and AMA1. These antigens were delivered to healthy malaria-naïve adult volunteers in Phase Ia clinical trials using recombinant replication-deficient viral vectors--ChAd63 to prime the immune response...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.1371/journal.pone.0107903
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 9
- Issue:
- 9
- Pages:
- e107903
- Publication date:
- 2014-09-25
- Acceptance date:
- 2014-08-17
- DOI:
- EISSN:
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1932-6203
- Source identifiers:
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485296
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:b2676859-c06d-43d2-84b6-8cadbc02375c
- Local pid:
- pubs:485296
- Deposit date:
- 2014-10-09
Terms of use
- Copyright holder:
- Biswas et al
- Copyright date:
- 2014
- Notes:
- © 2014 Biswas et al. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- Other
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