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Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.

Abstract:

BACKGROUND: Muscle LIM protein (MLP) is an essential nuclear regulator of myogenic differentiation. Additionally, it may act as an integrator of protein assembly of the actin-based cytoskeleton. MLP-knockout mice develop a marked cardiac hypertrophy reaction and dilated cardiomyopathy (DCM). MLP is therefore a candidate gene for heritable forms of hypertrophic cardiomyopathy (HCM) and DCM in humans. METHODS AND RESULTS: We analyzed 1100 unrelated individuals (400 patients with DCM, 200 patie...

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Authors


Ozcelik, C More by this author
Counsell, D More by this author
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Journal:
Circulation
Volume:
107
Issue:
10
Pages:
1390-1395
Publication date:
2003-03-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:b24700ed-5ba8-4e88-8042-d76976a87df9
Source identifiers:
256728
Local pid:
pubs:256728

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