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Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia.

Abstract:

BACKGROUND: Inhibitors of the phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathway are currently in clinical trials. In addition to antiproliferative and proapoptotic effects, these agents also diminish tumor hypoxia. Since hypoxia is a major cause of resistance to radiotherapy, we sought to understand how it is regulated by PI3K/mTOR inhibition. METHODS: Whole cell, mitochondrial, coupled and uncoupled oxygen consumption were measured in cancer cells afte...

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Publication status:
Published

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Authors


Hussien, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Shipley, RJ More by this author
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Journal:
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume:
111
Issue:
1
Pages:
72-80
Publication date:
2014-04-05
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
URN:
uuid:b2420745-e3f1-4ecf-bbed-d420cad347e6
Source identifiers:
457719
Local pid:
pubs:457719

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