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Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology

Abstract:

Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these findings to adult cardiomyocyte (CM) electrophysiology. However, different cell lines display different expression of ion channels, pumps and receptors, and show differences in electrophysiology. In th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fphys.2017.00986

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Johnstone, RH More by this author
Hortigon-Vinagre, MP More by this author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Physiology Journal website
Volume:
8
Pages:
Article: 986
Publication date:
2017-12-12
Acceptance date:
2017-11-17
DOI:
ISSN:
1664-042X
Pubs id:
pubs:810467
URN:
uri:b23fb266-3ae5-4bb7-ad93-eafa2dcc5659
UUID:
uuid:b23fb266-3ae5-4bb7-ad93-eafa2dcc5659
Local pid:
pubs:810467

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