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A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process.

Abstract:

As a member of Cnidaria, the body wall of hydra is structurally reduced to an epithelial bilayer with an intervening extracellular matrix (ECM). Biochemical and cloning studies have shown that the molecular composition of hydra ECM is similar to that seen in vertebrates and functional studies have demonstrated that cell-ECM interactions are important to developmental processes in hydra. Because vertebrate matrix metalloproteinases (MMPs) have been shown to have an important role in cell-ECM i...

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Publication status:
Published

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Authors


Leontovich, AA More by this author
Shimokawa, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Sarras, MP More by this author
Journal:
Development (Cambridge, England)
Volume:
127
Issue:
4
Pages:
907-920
Publication date:
2000-02-05
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:b23ddc25-6731-4a73-9ad6-10499a5bab4b
Source identifiers:
227301
Local pid:
pubs:227301

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