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Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

Abstract:

Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients. Pathway-based genome-wide association analysis of nontyphoidal Salmonella bacteremia showed a strong enrichme...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1126/sciadv.1602096

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Department:
Oxford, MSD, Paediatrics
Pittman, KJ More by this author
Rautanen, A More by this author
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
3
Issue:
3
Pages:
Article: e1602096
Publication date:
2017-03-05
DOI:
ISSN:
2375-2548
Pubs id:
pubs:688779
URN:
uri:b2323b74-0015-4545-9e11-07f6a8950a5b
UUID:
uuid:b2323b74-0015-4545-9e11-07f6a8950a5b
Local pid:
pubs:688779

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