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Journal article

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles.

Abstract:

Extracellular vesicles (EVs) are specialised endogenous carriers of proteins and nucleic acids and are involved in intercellular communication. EVs are therefore proposed as candidate drug delivery systems for the delivery of nucleic acids and other macromolecules. However, the preparation of EV-based drug delivery systems is hampered by the lack of techniques to load the vesicles with nucleic acids. In this work we have now characterised in detail the use of an electroporation method for thi...

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Publication status:
Published

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Authors


Kooijmans, SA More by this author
Stremersch, S More by this author
Braeckmans, K More by this author
de Smedt, SC More by this author
Hendrix, A More by this author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
172
Issue:
1
Pages:
229-238
Publication date:
2013-11-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:b22fcbf2-4224-4f07-a1aa-02f760c2f145
Source identifiers:
426874
Local pid:
pubs:426874

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