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A quantitative analysis of cardiac myocyte relaxation: a simulation study

Abstract:

The determinants of relaxation in cardiac muscle are poorly understood, yet compromised relaxation accompanies various pathologies and impaired pump function. In this study, we develop a model of active contraction to elucidate the relative importance of the [Ca2+]i transient magnitude, the unbinding of Ca2+ from troponin C (TnC), and the length-dependence of tension and Ca2+ sensitivity on relaxation. Using the framework proposed by one of our researchers, we extensively reviewed experimenta...

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Journal:
Biophys J
Volume:
90
Issue:
5
Pages:
1697-722
Publication date:
2006-01-01
URN:
uuid:b224a26c-259a-4ed7-9774-4ed9cb07097a
Local pid:
cs:1527

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