Journal article icon

Journal article

An engineered ClyA nanopore detects folded target proteins by selective external association and pore entry.

Abstract:

Nanopores have been used in label-free single-molecule studies, including investigations of chemical reactions, nucleic acid analysis, and applications in sensing. Biological nanopores generally perform better than artificial nanopores as sensors, but they have disadvantages including a fixed diameter. Here we introduce a biological nanopore ClyA that is wide enough to sample and distinguish large analyte proteins, which enter the pore lumen. Remarkably, human and bovine thrombins, despite 86...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/nl3024438

Authors


Expand authors...
Journal:
Nano letters
Volume:
12
Issue:
9
Pages:
4895-4900
Publication date:
2012-09-05
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
URN:
uuid:b2237e39-308a-4b8a-94e0-1d0b9051c786
Source identifiers:
352699
Local pid:
pubs:352699

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP