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BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: possible role in susceptibility to Gram-negative bacterial infections.

Abstract:

Although HLA class I expression is diminished in patients with defects in the transporter associated with antigen presentation (TAP), recurrent Gram-negative bacterial lung infections are found from childhood onwards. As MHC class II-mediated responses are normal, other mechanisms that contribute to susceptibility to infections are presumed. The bactericidal/permeability-increasing protein (BPI) is a potent neutrophil antibiotic that neutralizes endotoxin efficiently. As antineutrophil cytopl...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
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Journal:
Clinical and experimental immunology
Volume:
133
Issue:
2
Pages:
252-259
Publication date:
2003-08-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:b21fbe47-9693-4d9e-adf9-e88bddb3fe82
Source identifiers:
32411
Local pid:
pubs:32411

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