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The electrogenic Na+/K+ pump is a key determinant of repolarization abnormality susceptibility in human ventricular cardiomyocytes: A population-based simulation study

Abstract:

Background

Cellular repolarization abnormalities occur unpredictably due to disease and drug effects, and can occur even in cardiomyocytes that exhibit normal action potentials (AP) under control conditions. Variability in ion channel densities may explain differences in this susceptibility to repolarization abnormalities. Here, we quantify the importance of key ionic mechanisms determining repolarization abnormalities following ionic block in human cardiomyocytes yielding normal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fphys.2017.00278

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Department:
Oxford, MPLS, Computer Science
Role:
Author
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Department:
Oxford, MPLS, Computer Science
Role:
Author
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Department:
Oxford, MPLS, Computer Science
Role:
Author
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Funding agency for:
Rodriguez, B
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Physiology Journal website
Volume:
8
Pages:
278
Publication date:
2017-04-05
Acceptance date:
2017-04-18
DOI:
ISSN:
1664-042X
Pubs id:
pubs:689749
URN:
uri:b21c8f08-8c6b-44da-b115-260f79785220
UUID:
uuid:b21c8f08-8c6b-44da-b115-260f79785220
Local pid:
pubs:689749

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