Journal article
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
- Abstract:
-
DYRK kinases are involved in alternative pre-mRNA splicing as well as in neuropathological states such as Alzheimer's disease and Down syndrome. In this study, we present the design, synthesis, and biological evaluation of indirubins as DYRK inhibitors with enhanced selectivity. Modifications of the bis-indole included polar or acidic functionalities at positions 5' and 6' and a bromine or a trifluoromethyl group at position 7, affording analogues that possess high activity and pronounced spe...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/ml300207a
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Bibliographic Details
- Journal:
- ACS medicinal chemistry letters
- Volume:
- 4
- Issue:
- 1
- Pages:
- 22-26
- Publication date:
- 2013-01-01
- DOI:
- EISSN:
-
1948-5875
- ISSN:
-
1948-5875
- Source identifiers:
-
375787
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:375787
- UUID:
-
uuid:b21bd950-90be-4383-84dd-268ba016b3ad
- Local pid:
- pubs:375787
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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