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Journal article

Hypoxia response elements.

Abstract:

Hypoxia-inducible factor-1 (HIF-1) has been shown to mediate the transcriptional activation of its target genes in response to oxygen concentration, most likely via a pathway involving a specific oxygen sensor. Molecular cloning of HIF-1 has shown that this widely expressed, DNA binding transcription factor is a heterodimer of two proteins, HIF-1 alpha and HIF-1 beta. A major control of HIF-1 activity by oxygen tension is achieved by changes in the level of the HIF-1 alpha subunit, which comp...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Role:
Author
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Journal:
Oncology research
Volume:
9
Issue:
6-7
Pages:
327-332
Publication date:
1997-01-01
EISSN:
1555-3906
ISSN:
0965-0407
URN:
uuid:b2186518-3284-4d6b-a4d4-69e62cab7259
Source identifiers:
23461
Local pid:
pubs:23461

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