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Cannabis, cannabinoids and the endocannabinoid system – is there therapeutic potential for inflammatory bowel disease?

Abstract:

Cannabis sativa and its extracts have been used for centuries both medicinally and recreationally. There is accumulating evidence that exogenous cannabis and related cannabinoids improve symptoms associated with inflammatory bowel disease such as pain, loss of appetite, and diarrhoea. In vivo, exocannabinoids have been demonstrated to improve colitis, mainly in chemical models. Exocannabinoids signal through the endocannabinoid system, an increasingly understood network of endogenous lipid l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/ecco-jcc/jjy185

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Oxford college:
Green Templeton; Worcester College
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
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Funding agency for:
Ambrose, TJW
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Funding agency for:
Simmons, A
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Funding agency for:
Simmons, A
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Crohn's and Colitis Journal website
Volume:
13
Issue:
4
Pages:
525–535
Publication date:
2018-11-12
Acceptance date:
2018-11-07
DOI:
EISSN:
1876-4479
ISSN:
1873-9946
Pubs id:
pubs:940621
URN:
uri:b208c52a-216d-4a95-99a8-8b9c00c30631
UUID:
uuid:b208c52a-216d-4a95-99a8-8b9c00c30631
Local pid:
pubs:940621

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