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Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma

Abstract:

DNA vaccination against cancer has become a promising strategy for inducing a specific and longlasting antitumor immunity. However, DNA vaccines fail to generate potent immune responses when used as a single therapy. To enhance their activity into the tumor, a DNA vaccine against murine P815 mastocytoma was combined with antibodies directed against the immune checkpoints CTLA4 and PD1. The combination of these two strategies delayed tumor growth and enhanced specific antitumor immune cell inf...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-33933-7

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Walloon Region More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
15732
Publication date:
2018-10-24
Acceptance date:
2018-09-24
DOI:
EISSN:
2045-2322
Pubs id:
pubs:934879
URN:
uri:b1fc907b-4f33-4b8e-9e94-6a0188b7d808
UUID:
uuid:b1fc907b-4f33-4b8e-9e94-6a0188b7d808
Local pid:
pubs:934879

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