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Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation

Abstract:

Erythropoiesis is marked by progressive changes in morphological, biochemical and mechanical properties of erythroid precursors to generate red blood cells (RBC). The earliest enucleated forms derived in this process, known as reticulocytes, are multi-lobular and spherical. As reticulocytes mature, they undergo a series of dynamic cytoskeletal re-arrangements and the expulsion of residual organelles, resulting in highly deformable biconcave RBCs (normocytes). To understand the significant, ye...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1111/bjh.14976

Authors


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ORCID:
0000-0001-7959-075X
Malleret, B More by this author
Suwanarusk, R More by this author
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Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
British Journal of Haematology Journal website
Volume:
180
Issue:
1
Pages:
118–133
Publication date:
2017-11-02
Acceptance date:
2017-08-22
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
Pubs id:
pubs:745850
URN:
uri:b1f64270-3af0-49ea-8263-ddd39fdb520d
UUID:
uuid:b1f64270-3af0-49ea-8263-ddd39fdb520d
Local pid:
pubs:745850

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