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A hybrid approach to multi-scale modelling of cancer.

Abstract:

In this paper, we review multi-scale models of solid tumour growth and discuss a middle-out framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we compare a cell-centre, a cell-vertex and a continuum model of cell proliferation and movement. All models reproduce the basic features of a healthy crypt: cells proliferate near the crypt base, they migrate upwards and are sloughed off near the top. ...

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Publication status:
Published

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Publisher copy:
10.1098/rsta.2010.0173

Authors


Osborne, JM More by this author
Kershaw, SK More by this author
Mirams, GR More by this author
Fletcher, AG More by this author
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Journal:
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Volume:
368
Issue:
1930
Pages:
5013-5028
Publication date:
2010-11-05
DOI:
EISSN:
1471-2962
ISSN:
1364-503X
URN:
uuid:b1f0bc83-39a2-42c7-a147-4a73c0405896
Source identifiers:
90917
Local pid:
pubs:90917

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