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Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice.

Abstract:

The urokinase plasminogen activator receptor (uPAR) regulates macrophage adhesion and migration by binding directly to matrix proteins and signaling through integrin complexes. In this study, we examined the role of uPAR on macrophage infiltration into the vascular wall. Stable murine macrophage (Raw264.7) cell lines expressing high levels of human uPAR, human urokinase plasminogen activator (uPA), or both were established using expression vectors driven by the human CD68 promoter. Stimulatio...

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Publication status:
Published

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Publisher copy:
10.1002/jcp.20262

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Journal of cellular physiology
Volume:
204
Issue:
1
Pages:
73-82
Publication date:
2005-07-01
DOI:
EISSN:
1097-4652
ISSN:
0021-9541
Source identifiers:
29504

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