- Abstract:
-
Plasmodium falciparum malaria is a major cause of death in the tropics. The 19-kDa subunit of P. falciparum merozoite surface protein 1 (MSP-1(19)), a major blood stage vaccine candidate, is the target of cellular and humoral immune responses in animals and humans. In this phase I trial of MSP-1(19), immunization of nonexposed human volunteers with either of the two allelic forms of recombinant MSP-1(19) induced high levels of antigen-specific Th1 (gamma interferon) and Th2 (interleukin 4 [IL...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/iai.70.3.1417-1421.2002
-
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- Journal:
- Infection and immunity
- Volume:
- 70
- Issue:
- 3
- Pages:
- 1417-1421
- Publication date:
- 2002-03-05
- DOI:
- EISSN:
-
1098-5522
- ISSN:
-
0019-9567
- URN:
-
uuid:b1d79bf2-9884-42c8-87db-e1b455bee6e7
- Source identifiers:
-
32050
- Local pid:
- pubs:32050
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Induction of T helper type 1 and 2 responses to 19-kilodalton merozoite surface protein 1 in vaccinated healthy volunteers and adults naturally exposed to malaria.
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