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Journal article

Induction of T helper type 1 and 2 responses to 19-kilodalton merozoite surface protein 1 in vaccinated healthy volunteers and adults naturally exposed to malaria.

Abstract:

Plasmodium falciparum malaria is a major cause of death in the tropics. The 19-kDa subunit of P. falciparum merozoite surface protein 1 (MSP-1(19)), a major blood stage vaccine candidate, is the target of cellular and humoral immune responses in animals and humans. In this phase I trial of MSP-1(19), immunization of nonexposed human volunteers with either of the two allelic forms of recombinant MSP-1(19) induced high levels of antigen-specific Th1 (gamma interferon) and Th2 (interleukin 4 [IL...

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Publication status:
Published

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Authors


Palmer, DR More by this author
Flanagan, KL More by this author
Odhiambo, K More by this author
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Journal:
Infection and immunity
Volume:
70
Issue:
3
Pages:
1417-1421
Publication date:
2002-03-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:b1d79bf2-9884-42c8-87db-e1b455bee6e7
Source identifiers:
32050
Local pid:
pubs:32050

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