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Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.

Abstract:

Intracellular calcium signals have distinct temporal and spatial patterns in neurons in which signal initiation and repetitive spiking occurs predominantly in the neurite. We investigated the functional implications of the coexpression of different isoforms of ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (InsP3Rs) using immunocytochemistry, Western blotting, and calcium imaging in neuronally differentiated PC12 cells. InsP3R type III, an isoform that has been shown to ...

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Publication status:
Published

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Authors


Johenning, FW More by this author
Zochowski, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Holmes, AB More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
22
Issue:
13
Pages:
5344-5353
Publication date:
2002-07-05
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:b1ca1051-5e53-41d5-9034-ec9f8fd87a00
Source identifiers:
52031
Local pid:
pubs:52031

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