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Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.

Abstract:

Although dendritic cells (DCs) are the most potent antigen-presenting cells involved in numerous physiologic and pathologic processes, little is known about the signaling pathways that regulate DC activation and antigen-presenting function. Recently, we demonstrated that nuclear factor (NF)-kappaB activation is central to that process, as overexpression of IkappaBalpha blocks the allogeneic mixed lymphocyte reaction (MLR), an in vitro model of T-cell activation. In this study, we investigated...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2002-06-1835

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
Role:
Author
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Journal:
Blood
Volume:
101
Issue:
3
Pages:
983-991
Publication date:
2003-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b1ba6f4e-25f3-4fc8-8053-7b68bfb23c0c
Source identifiers:
224076
Local pid:
pubs:224076

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