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Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1.

Abstract:

It has been proposed that activation of vanilloid receptor-1 (TRPV1) affects the vasotone of resistance arteries. One of the endogenous activators of TRPV1 is anandamide. The effects of anandamide on TRPV1 responsiveness were tested on isolated, pressurized (80 mm Hg) skeletal muscle (m. gracilis) arterioles (179 +/- 33 microm in diameter). We found that the TRPV1 agonist capsaicin (1 microM) elicited a substantial constriction in isolated arterioles (51 +/- 12%). In contrast, anandamide (0-1...

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Publication status:
Published

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Publisher copy:
10.1124/mol.105.015644

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Molecular pharmacology
Volume:
69
Issue:
3
Pages:
1015-1023
Publication date:
2006-03-05
DOI:
EISSN:
1521-0111
ISSN:
0026-895X
URN:
uuid:b1b0035f-ffb8-4c11-994e-0f58ce2b8c94
Source identifiers:
164449
Local pid:
pubs:164449

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