Journal article
A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS
- Abstract:
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BACKGROUND:Neoadjuvant chemotherapy (NAC) allows earlier treatment of rectal cancer micro-metastases but is not standard of care. There are currently no biomarkers predicting long-term progression-free survival (PFS) benefit from NAC. PATIENTS AND METHODS:In this single arm phase II trial, patients with non-metastatic magnetic resonance imaging (MRI)-defined operable rectal adenocarcinoma at high risk of post-operative metastatic recurrence, received 8 weeks of oxaliplatin/fluorouracil NAC th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 794.8KB, Terms of use)
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- Publisher copy:
- 10.1038/s41416-018-0209-4
Authors
Contributors
+ McIntyre, A
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Contributor
Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- British Journal of Cancer More from this journal
- Volume:
- 119
- Issue:
- 6
- Pages:
- 697-706
- Publication date:
- 2019-08-17
- Acceptance date:
- 2019-07-09
- DOI:
- EISSN:
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1532-1827
- ISSN:
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0007-0920
- Pmid:
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30116024
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:896725
- UUID:
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uuid:b1ac353b-f883-495d-a0ba-5aece3e6a079
- Local pid:
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pubs:896725
- Source identifiers:
-
896725
- Deposit date:
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2019-06-19
Terms of use
- Copyright holder:
- Gollins et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2018. Published by Springer Nature on behalf of Cancer Research UK. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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