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Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis.

Abstract:

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting step along the kynurenine pathway and is thought to play a key role in immune homeostasis through depletion of tryptophan and accumulation of kynurenines. In this review we summarize recent research into the possibility of harnessing the IDO pathway for the therapy of rheumatoid arthritis. Inhibition of IDO activity, or knockout of the gene encoding IDO, was shown to cause an increase in the severity of collagen-induced arthriti...

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Publisher copy:
10.4137/ijtr.s11737

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
International journal of tryptophan research : IJTR
Volume:
6
Issue:
Suppl 1
Pages:
67-73
Publication date:
2013
DOI:
EISSN:
1178-6469
URN:
uuid:b192d510-d22c-4935-95bf-c42e6195950c
Source identifiers:
416731
Local pid:
pubs:416731

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