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Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium.

Abstract:

Additive interactions can have public health and etiological implications but are infrequently reported. We assessed departures from additivity on the absolute risk scale between 9 established breast cancer risk factors and 23 susceptibility single-nucleotide polymorphisms (SNPs) identified from genome-wide association studies among 10,146 non-Hispanic white breast cancer cases and 12,760 controls within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium. We estimate...

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Publication status:
Published

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Publisher copy:
10.1093/aje/kwu214

Authors


Lindström, S More by this author
Hüsing, A More by this author
Barrdahl, M More by this author
VanderWeele, TJ More by this author
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Publisher:
Oxford University Press
Journal:
American journal of epidemiology
Volume:
180
Issue:
10
Pages:
1018-1027
Publication date:
2014-11-05
DOI:
EISSN:
1476-6256
ISSN:
0002-9262
URN:
uuid:b1864b8c-c18c-45de-8295-c4e9a68dce6f
Source identifiers:
492639
Local pid:
pubs:492639

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