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Journal article

Whole-exome sequencing studies of nonfunctioning pituitary adenomas.

Abstract:

CONTEXT: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning adenomas (NFAs), which usually originate from gonadotroph cells, is unknown. OBJECTIVE: The objective of the study was to identify somatic genetic abnormalities in sporadic pituitary NFAs. DESIGN: Whole-exome sequencing was performed using DNA from 7 pituitary NFAs and leukocyte samples obtained from the same patients. Somatic variants were confirmed by dideoxynucleotide sequencing, and candidate drive...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1210/jc.2012-4028

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Rimmer, AJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Medical Research Council More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Wellcome Trust More from this funder
Publisher:
Endocrine Society Publisher's website
Journal:
The Journal of clinical endocrinology and metabolism Journal website
Volume:
98
Issue:
4
Pages:
E796-E800
Publication date:
2013
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:b17780e5-e7d9-4891-ba3c-c67b3dd3d9d7
Source identifiers:
387197
Local pid:
pubs:387197

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