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Tracking large solid constructs suspended in a rotating bioreactor: A combined experimental and theoretical study.

Abstract:

We present a combined experimental and theoretical study of the trajectory of a large solid cylindrical disc suspended within a fluid-filled rotating cylindrical vessel. The experimental set-up is relevant to tissue-engineering applications where a disc-shaped porous scaffold is seeded with cells to be cultured, placed within a bioreactor filled with nutrient-rich culture medium, which is then rotated in a vertical plane to keep the growing tissue construct suspended in a state of "free fall....

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Publication status:
Published

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Publisher copy:
10.1002/bit.22490

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Biotechnology and bioengineering
Volume:
104
Issue:
6
Pages:
1224-1234
Publication date:
2009-12-05
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
URN:
uuid:b1761532-4d79-4ee6-b377-eba4f8cba08f
Source identifiers:
48531
Local pid:
pubs:48531

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